News

How a repurposed drug is helping patients with spinal cord injuries

April 27, 2017

If your brain is the computer that runs your body, then your spine is the cable that delivers the operating orders. So if your spine is damaged via injury or compression, then the entire communications network is compromised and in disarray “The outflow of the brain is through the spinal cord, so if you think of the spinal cord as being like part of a computer, then having a spinal cord injury is like disconnecting the cable from the computer,” says Dr. Michael Fehlings, senior scientist at the Krembil Research Institute, vice-chair of research in the surgery department and head of the spinal program at Toronto Western Hospital and holder of the Gerry and Tootsie Halbert Chair in Neural Repair and Regeneration. Read full article in Neuro Magazine>>

RISCIS trial shows promise to enhance the quality of life for individuals with acute SCI

September 5, 2016

Spinal cord injury (SCI) results in devastating physical impairment and is associated with significant costs to the individual and to society. There is compelling evidence that the pathobiology of SCI involves an initial primary mechanical injury which is amplified by a complex series of secondary injury events including ischemia, ion channel dysfunction, glutamatergic excitoxicity and apoptosis. Riluzole, a sodium-glutamate antagonist, which is approved as a treatment to attenuate the rate of nerve cell degeneration in amyotrophic lateral sclerosis (ALS), has shown considerable promise as a therapeutic strategy to enhance outcomes in preclinical models of traumatic and non-traumatic SCI. Read the full article on the Aospine Foundation website>>